Title : Effect of hypercholesterolemia and of oxidative stress on the nitric oxide-cGMP pathway.

Pub. Date : 2004 Nov

PMID : 15312990






2 Functional Relationships(s)
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1 We aimed to investigate whether superoxide and peroxynitrite impacts on the expression and function of sGC and if such a mechanism occurs in a hypercholestemia-induced atherosclerosis. Superoxides guanylate cyclase 1 soluble subunit beta 2 Rattus norvegicus
2 Furthermore, intracellular superoxide as generated by LY85385 almost completely inhibited sGC-activity and increased its expression. Superoxides guanylate cyclase 1 soluble subunit beta 2 Rattus norvegicus