Title : Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration.

Pub. Date : 2004 Aug 13

PMID : 15310905






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 In Wallerian degeneration slow (wlds) mice, Wallerian degeneration in response to axonal injury is delayed because of a mutation that results in overexpression of a chimeric protein (Wlds) composed of the ubiquitin assembly protein Ufd2a and the nicotinamide adenine dinucleotide (NAD) biosynthetic enzyme Nmnat1. NAD ubiquitination factor E4B Mus musculus
2 In Wallerian degeneration slow (wlds) mice, Wallerian degeneration in response to axonal injury is delayed because of a mutation that results in overexpression of a chimeric protein (Wlds) composed of the ubiquitin assembly protein Ufd2a and the nicotinamide adenine dinucleotide (NAD) biosynthetic enzyme Nmnat1. NAD ubiquitination factor E4B Mus musculus