Title : Activities of cAMP-dependent protein kinase and protein kinase C are modulated by desensitized nicotinic receptors in the rat brain.

Pub. Date : 2004 Aug 26

PMID : 15308289






2 Functional Relationships(s)
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1 However, the activities of PKA and PKC decreased when brain nAChRs were in a sub-acute state, an acute state or a chronic desensitized state induced by repeated administration of nicotine. Nicotine protein kinase C, gamma Rattus norvegicus
2 These results suggest that desensitized nAChRs in the rat brain can inhibit the activities of PKA and PKC, which may be responsible for nicotine dependence. Nicotine protein kinase C, gamma Rattus norvegicus