Title : Isobolographic analysis of interaction between cyclooxygenase inhibitors and tramadol in acetic acid-induced writhing in mice.

Pub. Date : 2004 Jul

PMID : 15276689






1 Functional Relationships(s)
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1 The oral and intrathecally administered tramadol, a mu-opioid and naproxen, a nonselective COX inhibitor produced dose-dependent antinociception, however, rofecoxib, a selective COX-2 inhibitor lacked analgesic efficacy in writhing test. Tramadol cytochrome c oxidase II, mitochondrial Mus musculus