Title : A mechanism of sulfite neurotoxicity: direct inhibition of glutamate dehydrogenase.

Pub. Date : 2004 Oct 8

PMID : 15273247

1 Functional Relationships(s)
Compound Name
Protein Name
1 We propose that GDH is one target of action of sulfite, leading to a decrease in alpha-ketoglutarate and a diminished flux through the tricarboxylic acid cycle accompanied by a decrease in NADH through the mitochondrial electron transport chain, a decreased MMP, and a decrease in ATP synthesis. NAD glutamate dehydrogenase 1 Homo sapiens