Title : Involvement of RhoA and possible neuroprotective effect of fasudil, a Rho kinase inhibitor, in NMDA-induced neurotoxicity in the rat retina.

Pub. Date : 2004 Aug 20

PMID : 15262212






2 Functional Relationships(s)
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1 Fasudil (10(-6)-10(-4) M together with 4 x 10(-2) M NMDA) was given intravitreally and its effect was evaluated by counting the number of cells in the ganglion cell layer (GCL), measuring the thickness of the inner plexiform layer (IPL), and measuring retinal Thy-1 mRNA levels at 5 days after injection. fasudil Thy-1 cell surface antigen Rattus norvegicus
2 The reduction in Thy-1 mRNA levels by NMDA was also significantly attenuated by concomitant injection of fasudil. fasudil Thy-1 cell surface antigen Rattus norvegicus