Title : Evaluation of 5-hydroxytryptophol and other endogenous serotonin (5-hydroxytryptamine) analogs as substrates for UDP-glucuronosyltransferase 1A6.

Pub. Date : 2004 Aug

PMID : 15258112






2 Functional Relationships(s)
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1 N-acetylserotonin was glucuronidated most extensively by UGT1A6, although UGT1A9 and UGT1A10 showed moderate catalysis. N-acetylserotonin UDP glucuronosyltransferase family 1 member A6 Homo sapiens
2 In conclusion, these results indicate that human UGT1A6 plays a predominant role in the glucuronidation of 5-hydroxytryptophol and N-acetylserotonin, whereas 6-hydroxymelatonin is not a substrate for this enzyme. N-acetylserotonin UDP glucuronosyltransferase family 1 member A6 Homo sapiens