Pub. Date : 2004 Sep 17
PMID : 15252021
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Role of tyrosine phosphorylation in the regulation of cleavage secretion of angiotensin-converting enzyme. | Tyrosine | angiotensin I converting enzyme | Homo sapiens |
| 2 | Strong enhancements of ACE cleavage secretion was observed upon enhancing protein Tyr phosphorylation by treating gACE- or sACE-expressing cells with pervanadate, an inhibitor of protein Tyr phosphatases. | Tyrosine | angiotensin I converting enzyme | Homo sapiens |
| 3 | Secreted gACE, cell-bound mature gACE and its precursors were all Tyr-phosphorylated, as was the endoplasmic reticulum protein, immunoglobulin heavy chain-binding protein, that co-immunoprecipitated with ACE. | Tyrosine | angiotensin I converting enzyme | Homo sapiens |
| 4 | These results indicate that ACE Tyr phosphorylation, probably in the endoplasmic reticulum, enhances the rate of its cleavage secretion at the plasma membrane using a regulatory pathway that may involve p38 MAP kinase. | Tyrosine | angiotensin I converting enzyme | Homo sapiens |