Pub. Date : 2004 Jul 26
PMID : 15249140
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | DHEA and DHEA sulfate differentially regulate neural androgen receptor and its transcriptional activity. | Dehydroepiandrosterone | androgen receptor | Mus musculus |
| 2 | Semi-quantitative Western blot analysis showed that DHEA treatment significantly augmented AR in mouse brain and GT1-7 cells in a dose-dependent manner and that these effects were not blocked by trilostane (TRIL), a known 3beta-hydroxysteroid dehydrogenase inhibitor. | Dehydroepiandrosterone | androgen receptor | Mus musculus |
| 3 | DHEA also promoted AR-mediated reporter gene expression as a function of dose and the effect was comparable with or without the addition of TRIL. | Dehydroepiandrosterone | androgen receptor | Mus musculus |
| 4 | In contrast, DHEA-S treatment failed to increase AR level in the mouse brain or GT1-7 cells and modestly induced AR-mediated reporter gene expression only at substantially elevated concentrations compared to DHEA. | Dehydroepiandrosterone | androgen receptor | Mus musculus |
| 5 | In contrast, DHEA-S treatment failed to increase AR level in the mouse brain or GT1-7 cells and modestly induced AR-mediated reporter gene expression only at substantially elevated concentrations compared to DHEA. | Dehydroepiandrosterone | androgen receptor | Mus musculus |
| 6 | The findings demonstrate that DHEA is capable of exerting androgenic effects through AR while the androgenicity of DHEA-S is negligible. | Dehydroepiandrosterone | androgen receptor | Mus musculus |