Pub. Date : 2004 Jul 13
PMID : 15236592
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We report that apo-GRP94 undergoes a time- and temperature-dependent tertiary conformational change that exposes a site(s) of protein-protein interaction; ATP, ADP, and radicicol markedly suppress this conformational change. | Adenosine Diphosphate | heat shock protein 90 beta family member 1 | Homo sapiens |
| 2 | In concert with these findings, ATP and ADP act identically to suppress GRP94 homooligomerization, as well as both local and global conformational activity. | Adenosine Diphosphate | heat shock protein 90 beta family member 1 | Homo sapiens |
| 3 | Whereas ATP elicited efficient release of BiP from both wild-type and mutant Ig heavy chain intermediates, GRP94 remained in stable association with Ig heavy chains in the presence of ATP or ADP. | Adenosine Diphosphate | heat shock protein 90 beta family member 1 | Homo sapiens |