Title : The endocrine disruptors nonylphenol and octylphenol exert direct effects on T cells to suppress Th1 development and enhance Th2 development.

Pub. Date : 2004 Jun 15

PMID : 15234545






2 Functional Relationships(s)
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1 In both systems, 1-10 microM of p-n-nonylphenol suppressed Th1 development and enhanced Th2 development, whereas estrogen by itself failed to affect Th1/Th2 development. 4-nonylphenol negative elongation factor complex member C/D, Th1l Mus musculus
2 These results suggest that p-n-nonylphenol and p-n-octylphenol directly suppress Th1 development and enhance Th2 development through mechanisms independent of estrogen receptors, RAR, RXR, PRGR, and GCR. 4-nonylphenol negative elongation factor complex member C/D, Th1l Mus musculus