Pub. Date : 2004 Jul 2
PMID : 15225551
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We show, in vitro and in cells, that monomers or small soluble oligomers of huntingtin exon1 accumulate in the nucleus and inhibit the function of TBP in a polyQ-dependent manner. | polyglutamine | TATA-box binding protein | Homo sapiens |
| 2 | Interaction of toxic huntingtin with the benign polyQ repeat of TBP structurally destabilizes the transcription factor, independent of the formation of insoluble coaggregates. | polyglutamine | TATA-box binding protein | Homo sapiens |