Title : In vitro and in vivo activities of E5700 and ER-119884, two novel orally active squalene synthase inhibitors, against Trypanosoma cruzi.

Pub. Date : 2004 Jul

PMID : 15215084






1 Functional Relationships(s)
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1 Its causative agent, Trypanosoma cruzi, requires specific endogenous sterols for survival, and we have recently demonstrated that squalene synthase (SQS) is a promising target for antiparasitic chemotherapy. Sterols farnesyl-diphosphate farnesyltransferase 1 Homo sapiens