Pub. Date : 2004 Sep 10
PMID : 15210717
15 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Little is known about the effect of epigallocatechin-3 gallate (EGCG), a major constituent of green tea, on the expression of cyclooxygenase (COX)-2. | epigallocatechin gallate | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 2 | Little is known about the effect of epigallocatechin-3 gallate (EGCG), a major constituent of green tea, on the expression of cyclooxygenase (COX)-2. | epigallocatechin gallate | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 3 | Here, we studied the role of phospholipase D (PLD) isozymes in EGCG-induced COX-2 expression. | epigallocatechin gallate | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 4 | Stimulation of human astrocytoma cells (U87) with EGCG induced formation of phosphatidylbutanol, a specific product of PLD activity, and synthesis of COX-2 protein and its product, prostaglandin E(2) (PGE(2)). | epigallocatechin gallate | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 5 | Pretreatment of cells with 1-butanol, but not 3-butanol, suppressed EGCG-induced COX-2 expression and PGE synthesis. | epigallocatechin gallate | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 6 | Furthermore, evidence that PLD was involved in EGCG-induced COX-2 expression was provided by the observations that COX-2 expression was stimulated by overexpression of PLD1 or PLD2 isozymes and treatment with phosphatidic acid (PA), and that prevention of PA dephosphorylation by 1-propranolol significantly potentiated COX-2 expression induced by EGCG. | epigallocatechin gallate | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 7 | Furthermore, evidence that PLD was involved in EGCG-induced COX-2 expression was provided by the observations that COX-2 expression was stimulated by overexpression of PLD1 or PLD2 isozymes and treatment with phosphatidic acid (PA), and that prevention of PA dephosphorylation by 1-propranolol significantly potentiated COX-2 expression induced by EGCG. | epigallocatechin gallate | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 8 | Furthermore, evidence that PLD was involved in EGCG-induced COX-2 expression was provided by the observations that COX-2 expression was stimulated by overexpression of PLD1 or PLD2 isozymes and treatment with phosphatidic acid (PA), and that prevention of PA dephosphorylation by 1-propranolol significantly potentiated COX-2 expression induced by EGCG. | epigallocatechin gallate | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 9 | Furthermore, evidence that PLD was involved in EGCG-induced COX-2 expression was provided by the observations that COX-2 expression was stimulated by overexpression of PLD1 or PLD2 isozymes and treatment with phosphatidic acid (PA), and that prevention of PA dephosphorylation by 1-propranolol significantly potentiated COX-2 expression induced by EGCG. | epigallocatechin gallate | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 10 | Furthermore, evidence that PLD was involved in EGCG-induced COX-2 expression was provided by the observations that COX-2 expression was stimulated by overexpression of PLD1 or PLD2 isozymes and treatment with phosphatidic acid (PA), and that prevention of PA dephosphorylation by 1-propranolol significantly potentiated COX-2 expression induced by EGCG. | epigallocatechin gallate | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 11 | Furthermore, evidence that PLD was involved in EGCG-induced COX-2 expression was provided by the observations that COX-2 expression was stimulated by overexpression of PLD1 or PLD2 isozymes and treatment with phosphatidic acid (PA), and that prevention of PA dephosphorylation by 1-propranolol significantly potentiated COX-2 expression induced by EGCG. | epigallocatechin gallate | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 12 | EGCG induced activation of p38 mitogen-activated protein kinase (p38 MAPK), and specific inhibition of p38 MAPK dramatically abolished EGCG-induced PLD activation, COX-2 expression, and PGE(2) formation. | epigallocatechin gallate | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 13 | EGCG induced activation of p38 mitogen-activated protein kinase (p38 MAPK), and specific inhibition of p38 MAPK dramatically abolished EGCG-induced PLD activation, COX-2 expression, and PGE(2) formation. | epigallocatechin gallate | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 14 | Moreover, protein kinase C (PKC) inhibition suppressed EGCG-induced p38 MAPK activation, COX-2 expression, and PGE(2) accumulation. | epigallocatechin gallate | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 15 | Collectively, our results demonstrate for the first time that PLD isozymes mediate EGCG-induced COX-2 expression through PKC and p38 in immortalized astroglial line and normal astrocyte cells. | epigallocatechin gallate | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |