Title : Role of mouse CYP2E1 in the O-hydroxylation of p-nitrophenol: comparison of activities in hepatic microsomes from Cyp2e1(-/-) and wild-type mice.

Pub. Date : 2004 Jul

PMID : 15205381






2 Functional Relationships(s)
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1 Here we used hepatic microsomes from Cyp2e1(-/-) and wild-type mice to investigate the contributions of constitutively expressed and alcohol-induced murine CYP2E1 and CYP3A to PNPH activity. Alcohols cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus
2 Our findings suggest that in untreated and alcohol-treated mice, PNPH activity may be used as a specific probe for CYP2E1 and that constitutively expressed and alcohol-induced forms of mouse CYP3A have little to no role in catalyzing PNPH activity. Alcohols cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus