Title : The structure-specific endonuclease Ercc1-Xpf is required to resolve DNA interstrand cross-link-induced double-strand breaks.

Pub. Date : 2004 Jul

PMID : 15199134






3 Functional Relationships(s)
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1 Surprisingly, gamma-H2AX foci were also induced in Ercc1(-/-) cells by MMC treatment. Mitomycin ERCC excision repair 1, endonuclease non-catalytic subunit Homo sapiens
2 In Ercc1(-/-) cells, MMC-induced gamma-H2AX foci persisted at least 48 h longer than in wild-type cells, demonstrating that Ercc1 is required for the resolution of cross-link-induced DSBs. Mitomycin ERCC excision repair 1, endonuclease non-catalytic subunit Homo sapiens
3 In Ercc1(-/-) cells, MMC-induced gamma-H2AX foci persisted at least 48 h longer than in wild-type cells, demonstrating that Ercc1 is required for the resolution of cross-link-induced DSBs. Mitomycin ERCC excision repair 1, endonuclease non-catalytic subunit Homo sapiens