Title : Adenosine triphosphate acts as both a competitive antagonist and a positive allosteric modulator at recombinant N-methyl-D-aspartate receptors.

Pub. Date : 2004 Jun

PMID : 15155832






2 Functional Relationships(s)
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1 ATP inhibited NR1a + 2A and NR1a + 2B receptor currents evoked by low concentrations of glutamate but potentiated currents evoked by saturating glutamate concentrations. Glutamic Acid glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis
2 A simple model of the NMDA receptor, with ATP acting both as a competitive antagonist at the glutamate binding site and as a positive allosteric modulator at a separate site, reproduced the main features of the data. Glutamic Acid glutamate ionotropic receptor NMDA type subunit 1 L homeolog Xenopus laevis