Title : Molecular changes in neurons in multiple sclerosis: altered axonal expression of Nav1.2 and Nav1.6 sodium channels and Na+/Ca2+ exchanger.

Pub. Date : 2004 May 25

PMID : 15148385






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Using triple-labeled fluorescent immunocytochemistry, we also show that Nav1.6, which is known to produce a persistent sodium current, and the Na+/Ca2+ exchanger, which can be driven by persistent sodium current to import damaging levels of calcium into axons, are colocalized with beta-amyloid precursor protein, a marker of axonal injury, in acute MS lesions. Sodium solute carrier family 8 member A1 Homo sapiens