Title : Simultaneous inhibition of hsp 90 and the proteasome promotes protein ubiquitination, causes endoplasmic reticulum-derived cytosolic vacuolization, and enhances antitumor activity.

Pub. Date : 2004 May

PMID : 15141013






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The ansamycin antibiotic, geldanamycin, targets the hsp 90 protein chaperone and promotes ubiquitin-dependent proteasomal degradation of its numerous client proteins. Rifabutin heat shock protein 90 alpha family class A member 1 Homo sapiens