Title : Induction of spermidine/spermine N1-acetyltransferase in breast cancer tissues treated with the polyamine analogue N1, N11-diethylnorspermine.

Pub. Date : 2004 Aug

PMID : 15138709






3 Functional Relationships(s)
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1 The response of solid tumors to this drug has been associated with superinduction of the polyamine catabolic enzyme, spermine/spermidine N1-acetyltransferase (SSAT). Polyamines spermidine/spermine N1-acetyltransferase 1 Homo sapiens
2 The response of solid tumors to this drug has been associated with superinduction of the polyamine catabolic enzyme, spermine/spermidine N1-acetyltransferase (SSAT). Polyamines spermidine/spermine N1-acetyltransferase 1 Homo sapiens
3 Therefore, to estimate the response of breast cancers to DENSpm, we measured induction of SSAT in breast cancer explants treated in vitro with this polyamine analogue. Polyamines spermidine/spermine N1-acetyltransferase 1 Homo sapiens