Title : Quantification of the N-desmethyl metabolite of rosuvastatin in human plasma by automated SPE followed by HPLC with tandem MS detection.

Pub. Date : 2004 May 28

PMID : 15137986






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1 A selective, accurate and precise assay was developed for the quantification in human plasma of the N-desmethyl metabolite of the 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor rosuvastatin. Rosuvastatin Calcium 3-hydroxy-3-methylglutaryl-CoA reductase Homo sapiens