Title : Human constitutive androstane receptor mediates induction of CYP2B6 gene expression by phenytoin.

Pub. Date : 2004 Jul 9

PMID : 15123723






1 Functional Relationships(s)
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1 In primary human hepatocytes, expression of CYP2B6 reporter genes containing phenobarbital-responsive enhancer module (PBREM) or PBREM/xenobiotic-responsive enhancer module (XREM) response elements were activated up to 14- and 28-fold, respectively, by 50 microm PHY. Phenobarbital cytochrome P450 family 2 subfamily B member 6 Homo sapiens