Title : Blocking of FGFR signaling inhibits breast cancer cell proliferation through downregulation of D-type cyclins.

Pub. Date : 2004 Apr 29

PMID : 15116089






2 Functional Relationships(s)
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1 PD173074-mediated inhibition of FGFR activity caused downregulation of cyclin D1 and cyclin D2 expression, inhibition of cyclin D/cdk4 activity and, as a consequence, reduction of pRB phosphorylation. PD 173074 cyclin D1 Homo sapiens
2 Retroviral-mediated ectopic expression of cyclin D1 prevented pRB hypophosphorylation and the cell cycle G1 block in PD173074-treated cells, suggesting a central role for D cyclins in proliferation of FGFR-driven breast cancer cells. PD 173074 cyclin D1 Homo sapiens