Title : Functional role of a mobile loop of Escherichia coli dihydrofolate reductase in transition-state stabilization.

Pub. Date : 1992 Sep 1

PMID : 1510968






1 Functional Relationships(s)
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1 The function of a highly mobile loop in Escherichia coli dihydrofolate reductase was studied by constructing a mutant (DL1) using cassette mutagenesis that had four residues deleted in the middle section of the loop (Met16-Ala19) and a glycine inserted to seal the gap. Glycine Dihydrofolate reductase Escherichia coli