Title : Cathepsin-dependent apoptosis triggered by supraoptimal activation of T lymphocytes: a possible mechanism of high dose tolerance.

Pub. Date : 2004 May 1

PMID : 15100281






1 Functional Relationships(s)
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1 Although the pan-caspase inhibitor N-benzyloxycarbonyl-Val-Ala-Asp-fluoromethylketone (zVAD-fmk) decreased DNA fragmentation, cytochrome c release and caspase-9 and caspase-3 activation were not implicated, suggesting that this apoptosis did not primarily involve the intrinsic mitochondrial pathway. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone cytochrome c, somatic Homo sapiens