Title : Histamine production via mast cell-independent induction of histidine decarboxylase in response to lipopolysaccharide and interleukin-1.

Pub. Date : 2004 Apr

PMID : 15099528






1 Functional Relationships(s)
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1 These results suggest that (i) in liver, lung and spleen, either the major cells supplying histamine via HDC induction in response to LPS and IL-1 are not mast cells, or mast cells are not a prerequisite for the induction of HDC; (ii) the cells in which HDC is induced by LPS and IL-1 are similar or identical in a given organ; and (iii) neither IL-1 nor TNF-alpha is a prerequisite for the induction of HDC by LPS. Histamine interleukin 1 complex Mus musculus