Title : Characterization of a cGMP-response element in the guanylyl cyclase/natriuretic peptide receptor A gene promoter.

Pub. Date : 2004 Jun

PMID : 15096467






3 Functional Relationships(s)
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1 Previous studies have shown that atrial natriuretic peptide (ANP) can inhibit transcription of its receptor, guanylyl cyclase A, by a mechanism dependent on cGMP and have suggested the presence of a putative cGMP-response element (cGMP-RE) in the Npr1 gene promoter. Cyclic GMP natriuretic peptide receptor 1 Homo sapiens
2 Previous studies have shown that atrial natriuretic peptide (ANP) can inhibit transcription of its receptor, guanylyl cyclase A, by a mechanism dependent on cGMP and have suggested the presence of a putative cGMP-response element (cGMP-RE) in the Npr1 gene promoter. Cyclic GMP natriuretic peptide receptor 1 Homo sapiens
3 The cGMP regulatory region was narrowed by gel shift assays and footprinting to position -1372 to -1354 from the transcription start site of Npr1 and indicated its interaction with transcriptional factor(s). Cyclic GMP natriuretic peptide receptor 1 Homo sapiens