Title : Effects of various factors on steady-state plasma concentrations of risperidone and 9-hydroxyrisperidone: lack of impact of MDR-1 genotypes.

Pub. Date : 2004 May

PMID : 15089809






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Multiple regression analyses including CYP2D6 genotypes, sex, and age revealed that steady-state plasma concentration of risperidone correlated with the number of mutated alleles for CYP2D6 (standardized partial correlation coefficients (beta) = 0.540, P < 0.001) and those of 9-hydroxyrisperidone (standardized beta = 0.244, P = 0.038) and active moiety (standardized beta = 0.257, P = 0.027) correlated with age. Paliperidone Palmitate cytochrome P450 family 2 subfamily D member 6 Homo sapiens