Title : Structural and conformational aspects of the anticoagulant and anti-thrombotic activity of heparin and dermatan sulfate.

Pub. Date : 2004

PMID : 15078125






1 Functional Relationships(s)
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1 Heparin and other iduronic acid-containing glycosaminoglycans (GAG) such as dermatan sulfate exert their anticoagulant properties primarily by accelerating the rate of inhibition of the natural protease inhibitors antithrombin III (AT, which inhibits both factor Xa and thrombin) and heparin cofactor II (HCII, which selectively inhibits thrombin). Dermatan Sulfate serpin family C member 1 Homo sapiens