Title : Role of a PDZ1 domain of NHERF1 in the binding of airway epithelial RACK1 to NHERF1.

Pub. Date : 2004 May

PMID : 15075202






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 An internal 11-amino acid motif embedding the GYGF carboxylate binding loop of PDZ1 binds to RACK1, inhibits binding of recombinant NHERF1 and RACK1, pulls down endogenous RACK1 from Calu-3 cell lysate, and blocks coimmunoprecipitation of endogenous RACK1 with endogenous NHERF1 but does not affect cAMP-dependent activation of CFTR. 11-amino acid CF transmembrane conductance regulator Homo sapiens