Title : Tracking the elusive antiestrogenic effect of melatonin: a new methodological approach.

Pub. Date : 2003 Dec

PMID : 15073572






3 Functional Relationships(s)
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1 OBJECTIVES: Detection of the antiestrogenic effect of melatonin on various breast cancer cell lines and its dependence of the differential expression of estrogen receptors (ERalpha and ERbeta) and melatonin receptors (mt1 and RZRalpha). Melatonin estrogen receptor 1 Homo sapiens
2 Responsiveness to melatonin depended on expression of ERalpha but not on ERbeta. Melatonin estrogen receptor 1 Homo sapiens
3 CONCLUSION: The growth of all ERalpha-positive breast cancer cell lines can be inhibited by melatonin. Melatonin estrogen receptor 1 Homo sapiens