Pub. Date : 2004 Jun 11
PMID : 15073169
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Sulforaphane-induced G2/M phase cell cycle arrest involves checkpoint kinase 2-mediated phosphorylation of cell division cycle 25C. | sulforaphane | checkpoint kinase 2 | Homo sapiens |
| 2 | Transient transfection of PC-3 cells with Chk2-specific small interfering RNA duplexes significantly attenuated SFN-induced G(2)/M arrest. | sulforaphane | checkpoint kinase 2 | Homo sapiens |
| 3 | HCT116 human colon cancer-derived Chk2(-/-) cells were significantly more resistant to G(2)/M arrest by SFN compared with the wild type HCT116 cells. | sulforaphane | checkpoint kinase 2 | Homo sapiens |
| 4 | These findings indicate that Chk2-mediated phosphorylation of Cdc25C plays a major role in irreversible G(2)/M arrest by SFN. | sulforaphane | checkpoint kinase 2 | Homo sapiens |