Title : An altered antioxidant balance occurs in Down syndrome fetal organs: implications for the "gene dosage effect" hypothesis.

Pub. Date : 2003

PMID : 15068240






1 Functional Relationships(s)
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1 We examined the SOD1 to GPX1 mRNA ratio in individual organs, as both enzymes form part of the body"s defense against oxidative stress, and because a disproportionate increase of SOD1 to GPX1 results in noxious hydroxyl radical damage. Hydroxyl Radical glutathione peroxidase 1 Homo sapiens