Title : Anti-inflammatory effects of butadiene Diels-Alder adducts to some 1-dehydroglucocorticoids in rats.

Pub. Date : 2004 Apr

PMID : 15066657






1 Functional Relationships(s)
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1 Three compounds (C1, C2 and C3) were synthesized by reacting dexamethasone as a strong anti-inflammatory drug or prednisolone as a moderate one with 1,3-butadiene under Diels-Alder reaction conditions to produce pentacyclic compounds. 1,3-butadiene complement C2 Rattus norvegicus