Title : Glycine transporter type 1 blockade changes NMDA receptor-mediated responses and LTP in hippocampal CA1 pyramidal cells by altering extracellular glycine levels.

Pub. Date : 2004 Jun 1

PMID : 15064326






4 Functional Relationships(s)
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1 Glycine transporter type 1 blockade changes NMDA receptor-mediated responses and LTP in hippocampal CA1 pyramidal cells by altering extracellular glycine levels. Glycine solute carrier family 6 member 9 Rattus norvegicus
2 Previous pharmacological studies suggest that the glycine transporter type 1 (GlyT1) maintains subsaturating concentrations of glycine at synaptic NMDARs. Glycine solute carrier family 6 member 9 Rattus norvegicus
3 Antagonists of GlyT1 increase levels of glycine in the synaptic cleft and, like direct glycine site agonists, can augment NMDAR currents and NMDAR-mediated functions such as LTP. Glycine solute carrier family 6 member 9 Rattus norvegicus
4 Antagonists of GlyT1 increase levels of glycine in the synaptic cleft and, like direct glycine site agonists, can augment NMDAR currents and NMDAR-mediated functions such as LTP. Glycine solute carrier family 6 member 9 Rattus norvegicus