Title : Brefeldin A, thapsigargin, and AIF4- stimulate the accumulation of GRP78 mRNA in a cycloheximide dependent manner, whilst induction by hypoxia is independent of protein synthesis.

Pub. Date : 1992 Sep

PMID : 1506413






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Expression of the glucose regulated proteins (GRP78 and GRP94) is greatly increased after cells are exposed to stress agents (including A23187 and tunicamycin) which inhibit ER function. Tunicamycin heat shock protein family A (Hsp70) member 5 Homo sapiens
2 The increased accumulation of GRP78 mRNA after exposure of cells to either thapsigargin, brefeldin A, AIF4-, A23187, or tunicamycin can be blocked by pre-incubation in cycloheximide. Tunicamycin heat shock protein family A (Hsp70) member 5 Homo sapiens