Pub. Date : 2004 Apr 30
PMID : 15063803
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In the present study, we examined the effect of sanguinarine on VEGF-induced angiogenesis in vitro and in vivo. | sanguinarine | vascular endothelial growth factor A | Mus musculus |
| 2 | Interestingly, sanguinarine markedly suppressed VEGF-induced endothelial cell migration, sprouting, and survival in vitro in a dose-dependent manner at nanomolar concentrations. | sanguinarine | vascular endothelial growth factor A | Mus musculus |
| 3 | Our biochemical assays indicated that sanguinarine strongly suppressed basal and VEGF-induced Akt phosphorylation, while it did not produce any changes in VEGF-induced activation of ERK1/2 and PLCgamma1. | sanguinarine | vascular endothelial growth factor A | Mus musculus |
| 4 | Therefore, we conclude that sanguinarine is a potent antiangiogenic natural product, and its mode of action could involve the blocking of VEGF-induced Akt activation. | sanguinarine | vascular endothelial growth factor A | Mus musculus |