Title : High-throughput screening assay for inhibitors of heat-shock protein 90 ATPase activity.

Pub. Date : 2004 Apr 15

PMID : 15051534






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Inhibitors of HSP90 ATPase activity including the benzoquinone ansamycins, geldanamycin and 17-allylamino-17-demethoxygeldanamycin, and radicicol have been described. monorden Hsp90 family chaperone HSP82 Saccharomyces cerevisiae S288C
2 The known HSP90 inhibitors geldanamycin and radicicol gave IC(50) values of 4.8 and 0.9 microM respectively, which compare with values found using the conventional coupled-enzyme assay. monorden Hsp90 family chaperone HSP82 Saccharomyces cerevisiae S288C