Title : Immunophilin ligands decrease release of pro-inflammatory cytokines (IL-1beta, TNF-alpha and IL-2 in rat astrocyte cultures exposed to simulated ischemia in vitro.

Pub. Date : 2004 Jan-Feb

PMID : 15047987






1 Functional Relationships(s)
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1 CsA (at concentrations of 10-50 microM), FK506 (at all used concentrations) and rapamycin (in dose-dependent manner) significantly attenuated IL-1beta release after 24 h exposure to ischemic conditions. Tacrolimus interleukin 1 beta Rattus norvegicus