Title : Glutathione S-transferase M1 and multidrug resistance protein 1 act in synergy to protect melanoma cells from vincristine effects.

Pub. Date : 2004 Apr

PMID : 15044619






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Inhibitors of MRP1 (sulfinpyrazone, verapamil) and GST (dicumarol, curcumin) completely reversed the GSTM1-associated resistance to VCR, indicating that a MRP efflux function is necessary to potentiate GSTM1-mediated resistance to VCR. Dicumarol glutathione S-transferase mu 1 Homo sapiens