Pub. Date : 2004 Apr 16
PMID : 15044076
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Intracerebroventricular treatment with 960 nmol GMP prevented 80% of seizures and the 5"-nucleotidase inhibitor alpha-beta-methyleneadenosine 5"-diphosphate (AOPCP), when injected 3 min before, reduced this anticonvulsant effect to 30% protection as well as significantly decreased the conversion of GMP into guanosine measured in the CSF. | Guanosine Monophosphate | 5'-nucleotidase ecto | Homo sapiens |
| 2 | Intracerebroventricular treatment with 960 nmol GMP prevented 80% of seizures and the 5"-nucleotidase inhibitor alpha-beta-methyleneadenosine 5"-diphosphate (AOPCP), when injected 3 min before, reduced this anticonvulsant effect to 30% protection as well as significantly decreased the conversion of GMP into guanosine measured in the CSF. | Guanosine Monophosphate | 5'-nucleotidase ecto | Homo sapiens |
| 3 | This study shows that the previously reported effect of GMP as an anticonvulsant seems to be related to its ability to generate guanosine through the action of ecto-5"-nucleotidase. | Guanosine Monophosphate | 5'-nucleotidase ecto | Homo sapiens |