Title : Metformin causes reduction of food intake and body weight gain and improvement of glucose intolerance in combination with dipeptidyl peptidase IV inhibitor in Zucker fa/fa rats.

Pub. Date : 2004 Aug

PMID : 15039452






3 Functional Relationships(s)
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1 We previously found that the biguanide metformin, an antidiabetic agent, causes a significant increase of plasma active GLP-1 level in the presence of dipeptidyl peptidase IV (DPPIV) inhibitor in normal rats. Metformin dipeptidylpeptidase 4 Rattus norvegicus
2 We previously found that the biguanide metformin, an antidiabetic agent, causes a significant increase of plasma active GLP-1 level in the presence of dipeptidyl peptidase IV (DPPIV) inhibitor in normal rats. Metformin dipeptidylpeptidase 4 Rattus norvegicus
3 These results demonstrate that the combination therapy of metformin with DPPIV inhibitor leads to reduced food intake and body weight gain, most likely through the significant increase of plasma GLP-1 level. Metformin dipeptidylpeptidase 4 Rattus norvegicus