Pub. Date : 2004 Aug
PMID : 15033902
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Silibinin prevents ultraviolet radiation-caused skin damages in SKH-1 hairless mice via a decrease in thymine dimer positive cells and an up-regulation of p53-p21/Cip1 in epidermis. | Silybin | cyclin-dependent kinase inhibitor 1A (P21) | Mus musculus |
| 2 | Silibinin prevents ultraviolet radiation-caused skin damages in SKH-1 hairless mice via a decrease in thymine dimer positive cells and an up-regulation of p53-p21/Cip1 in epidermis. | Silybin | cyclin-dependent kinase inhibitor 1A (P21) | Mus musculus |
| 3 | In other studies, silibinin treatment resulted in a further up-regulation of p53 by approximately 1.6-fold (P < 0.001) together with an increase ( approximately 2-fold, P < 0.001) in p21/Cip1 protein levels. | Silybin | cyclin-dependent kinase inhibitor 1A (P21) | Mus musculus |
| 4 | In other studies, silibinin treatment resulted in a further up-regulation of p53 by approximately 1.6-fold (P < 0.001) together with an increase ( approximately 2-fold, P < 0.001) in p21/Cip1 protein levels. | Silybin | cyclin-dependent kinase inhibitor 1A (P21) | Mus musculus |
| 5 | These findings suggest that silibinin affords strong protection against UV-induced damage in epidermis by a decrease in thymine dimer positive cells and an up-regulation of p53-p21/Cip1 possibly leading to an inhibition in both cell proliferation and apoptosis. | Silybin | cyclin-dependent kinase inhibitor 1A (P21) | Mus musculus |
| 6 | These findings suggest that silibinin affords strong protection against UV-induced damage in epidermis by a decrease in thymine dimer positive cells and an up-regulation of p53-p21/Cip1 possibly leading to an inhibition in both cell proliferation and apoptosis. | Silybin | cyclin-dependent kinase inhibitor 1A (P21) | Mus musculus |