Pub. Date : 2004 May 14
PMID : 15024008
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Neomycin prevents the wortmannin inhibition of insulin-stimulated Glut4 translocation and glucose transport in 3T3-L1 adipocytes. | Wortmannin | solute carrier family 2 member 4 | Homo sapiens |
| 2 | Insulin-stimulated Glut4 translocation and glucose transport are abolished by wortmannin, a specific inhibitor of phosphatidylinositol 3"-kinase (PI3K). | Wortmannin | solute carrier family 2 member 4 | Homo sapiens |
| 3 | Here, we demonstrate that neomycin, a drug that masks the cellular substrate of PI3K, phosphatidylinositol 4,5-bisphosphate (PIP), prevents wortmannin inhibition of insulin-stimulated (2)Glut4 translocation and glucose transport without activating protein kinase B, a downstream effector of PI3K. | Wortmannin | solute carrier family 2 member 4 | Homo sapiens |