Pub. Date : 2004 Apr 1
PMID : 15019843
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We have previously shown that TCDD-stimulated AhR-dependent IL-1beta expression in human keratinocytes is due to posttranscriptional regulation involving mRNA stabilization. | Polychlorinated Dibenzodioxins | interleukin 1 beta | Homo sapiens |
| 2 | Since TCDD activates a variety of cellular signaling pathways such as PKC, JNK, and ERK, we investigated these pathways to determine their roles in TCDD-stimulated IL-1beta expression in the human keratinocyte cell line SCC-12F. | Polychlorinated Dibenzodioxins | interleukin 1 beta | Homo sapiens |
| 3 | Since TCDD activates a variety of cellular signaling pathways such as PKC, JNK, and ERK, we investigated these pathways to determine their roles in TCDD-stimulated IL-1beta expression in the human keratinocyte cell line SCC-12F. | Polychlorinated Dibenzodioxins | interleukin 1 beta | Homo sapiens |
| 4 | Thus, both the ERK and JNK MAPK pathways are necessary for IL-1beta expression in TCDD-stimulated human keratinocytes, however, they act at different levels to modulate IL-1beta expression. | Polychlorinated Dibenzodioxins | interleukin 1 beta | Homo sapiens |