Title : Identification of cytochrome P450 isoforms involved in 1-hydroxylation of pyrene.

Pub. Date : 2004 Mar

PMID : 15016593






1 Functional Relationships(s)
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1 The pyrene 1-hydroxylation activity was found to be the highest in CYP1A1 at both 0.5 and 50microM of pyrene, followed by CYP1B1 and 1A2, whereas other enzymes, including CYP2A6, 2C8, 2C9*1, 2C19, 2D6, 2E1, 3A4, and control microsomes, showed very low or undetectable rates of 1-hydroxylation. pyrene cytochrome P450 family 1 subfamily B member 1 Homo sapiens