Pub. Date : 2004 Mar
PMID : 15009649
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We discovered that valproate regulates expression of 28 genes, including three isoenzymes (M1, A3 and A4) of glutathione S-transferase (GST), an important protective factor against oxidative stress. | Valproic Acid | hematopoietic prostaglandin D synthase | Rattus norvegicus |
| 2 | We discovered that valproate regulates expression of 28 genes, including three isoenzymes (M1, A3 and A4) of glutathione S-transferase (GST), an important protective factor against oxidative stress. | Valproic Acid | hematopoietic prostaglandin D synthase | Rattus norvegicus |
| 3 | Because previous studies in our laboratory found that chronic valproate treatment protected cultured neurons against oxidative stress, further experiments on the regulation of GST were performed. | Valproic Acid | hematopoietic prostaglandin D synthase | Rattus norvegicus |
| 4 | Chronic valproate treatment increased mRNA levels of M1 and A4, but decreased the A3 mRNA level dose-dependently, indicating further complexities in the regulation of GST by valproate. | Valproic Acid | hematopoietic prostaglandin D synthase | Rattus norvegicus |
| 5 | Chronic valproate treatment increased mRNA levels of M1 and A4, but decreased the A3 mRNA level dose-dependently, indicating further complexities in the regulation of GST by valproate. | Valproic Acid | hematopoietic prostaglandin D synthase | Rattus norvegicus |
| 6 | The level of GST M1 protein and GST activity were also increased by chronic valproate treatment. | Valproic Acid | hematopoietic prostaglandin D synthase | Rattus norvegicus |
| 7 | The level of GST M1 protein and GST activity were also increased by chronic valproate treatment. | Valproic Acid | hematopoietic prostaglandin D synthase | Rattus norvegicus |
| 8 | The present findings suggest that regulation of GST M1, and possibly GST A4, may mediate the anti-oxidative effects of valproate treatment, and regulation of GST may be involved in the mood stabilizing effect of valproate and lithium. | Valproic Acid | hematopoietic prostaglandin D synthase | Rattus norvegicus |