Title : The effect of pegylated antisense acetylcholinesterase on hematopoiesis.

Pub. Date : 2003

PMID : 15000836






4 Functional Relationships(s)
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1 To determine whether the efficacy of entry and action of antisense oligonucleotides (AS-ODN) on hematopoietic stem cells in vitro could be improved by the addition of polyethylene glycol (PEG), a molecule of PEG was bound to AS- or sense-acetylcholinesterase (AS-ACHE or S-ACHE). Polyethylene Glycols acetylcholinesterase (Cartwright blood group) Homo sapiens
2 To determine whether the efficacy of entry and action of antisense oligonucleotides (AS-ODN) on hematopoietic stem cells in vitro could be improved by the addition of polyethylene glycol (PEG), a molecule of PEG was bound to AS- or sense-acetylcholinesterase (AS-ACHE or S-ACHE). Polyethylene Glycols acetylcholinesterase (Cartwright blood group) Homo sapiens
3 PEG-AS-ACHE induced higher colony numbers and greatly increased megakaryocyte (MK) formation when compared with PEG and AS-ACHE added separately to the culture. Polyethylene Glycols acetylcholinesterase (Cartwright blood group) Homo sapiens
4 In addition, differentials of the CFU-GEMMs indicated there was a direct relationship between MK number and PEG-AS-ACHE concentration. Polyethylene Glycols acetylcholinesterase (Cartwright blood group) Homo sapiens