Pub. Date : 2004 Mar 8
PMID : 14997213
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | YTX treatment of MCF-7 breast cancer cells causes the accumulation of a 100 kDa fragment of E-cadherin, which we have named ECRA(100). | yessotoxin | cadherin 1 | Homo sapiens |
| 2 | The accumulation of a 100 kDa fragment of E-cadherin devoid of its intracellular domain induced by YTX was accompanied by reduced levels of beta- and gamma-catenins bound to E-cadherin, without a concomitant decrease in the total cytosoluble pools of beta- and gamma-catenins. | yessotoxin | cadherin 1 | Homo sapiens |
| 3 | Taken together, the results we obtained show that YTX causes the selective disruption of the E-cadherin-catenin system in epithelial cells, and raise some concern about the potential that an algal toxin found in seafood might disrupt the tumour suppressive functions of E-cadherin. | yessotoxin | cadherin 1 | Homo sapiens |
| 4 | Taken together, the results we obtained show that YTX causes the selective disruption of the E-cadherin-catenin system in epithelial cells, and raise some concern about the potential that an algal toxin found in seafood might disrupt the tumour suppressive functions of E-cadherin. | yessotoxin | cadherin 1 | Homo sapiens |