Title : mCPP-induced hyperactivity in 5-HT2C receptor mutant mice is mediated by activation of multiple 5-HT receptor subtypes.

Pub. Date : 2004 Apr

PMID : 14996544






1 Functional Relationships(s)
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1 A combination of the 5-HT1B receptor agonist CP-94,253 (20 mg/kg) and the 5-HT1A receptor agonist 8-OH-DPAT (0.5 mg/kg) induced marked hyperactivity in WT but not in 5-HT2C KO mice, nor in mice treated with the selective 5-HT2C receptor antagonist, SB 242084 (1.5 mg/kg). 1,2-diethyl-3-hydroxypyridin-4-one 5-hydroxytryptamine (serotonin) receptor 1B Mus musculus